Grey's Anatomy season 20 will see the return of Meredith Grey, played by Ellen Pompeo. The trailer teases her comeback to Seattle Grace, where the show is set. Pompeo left the show midway through season 19, but her exit was never permanent. Although it is unclear how many episodes she will appear in, she will be in the premiere and at least one additional episode. The highly acclaimed medical drama follows the lives of doctors at Grey Sloan Memorial as they navigate both personal and professional challenges.